Stephan A. Sieber

Biography

Professor Sieber received his PhD with distinction from Philipps-University in Marburg under the guidance of Prof. Mohamed A. Marahiel, on “Nonribosomal Peptide Synthetases: Quaternary Structure and Chemoenzymatic Synthesis of Macrocyclic Peptides”. His research for doctoral thesis was partly completed in the laboratory of Prof. Christopher T. Walsh at Harvard Medical School in Boston, USA. He did his postdoctoral research with Prof. Benjamin F. Cravatt at the Scripps Research Institute in La Jolla, USA, on “A Chemical-Proteomic Strategy for Targeting Cancer-Associated Enzymes“. The research goal of Prof. Sieber’s group is to identify unprecedented antibacterial targets beyond the scope of current antibiotics and to exploit these for chemical manipulation. To this goal, the group is applying a multi-disciplinary strategy comprising synthetic chemistry, functional proteomics, microbiology, and protein biochemistry techniques as outlined in the following sections. The research focuses on three main topics: novel antibacterial targets, natural product mode of action, and chemical proteome mining.

Novel antibacterial targets – Chair of Organic Chemistry II (tum.de)